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Gattefosse

Established in 1880, Gattefossé is a privately held independent Group which develops, manufactures and markets innovative products and application technologies. For more information, please visit gattefosse.com.

Product Name Category Characteristic & Application CDMF status
Apifil
topical
A nonionic oil-in-water emulsifier for topical emulsions.
-
Capryol 90
oral & topical
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation.
-
Capryol PGMC
oral & topical
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation.
-
Cetyl Palmitate
topical
Thickener.
Compritol 888 ATO
oral
Modified release matrix former for tablet. Lubricant for tablet—independent of mixing time and speed. Lipid carrier former for solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC). Coating agent for taste masking and protection of sensitive APIs. Listed in the European STEP database for excipients in pediatric medicines.
Compritol HD5 ATO
oral
Lubricant and wetting agent in fast-dissolving and effervescent tablets.
-
Geleol Mono and Diglycerides NF
oral & topical
Modified release matrix former for capsule. Coating agent for taste masking. Consistency agent.
Gelot 64
topical
Emulsifier for difficult-to-formulate APIs, API combinations, anhydrous emulsion. Associate with Emulcire™ 61 WL2659 to enhance sensorial and texture properties.
-
Gelucire 43/01
oral & topical
Matrix-forming agent for protection of APIs sensitive to oxidation, humidity, or light. Consistency agent in oral and topical formulations
-
Gelucire 44/14
oral
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). Wetting agent. Lipid binder in melt processes.
-
Gelucire 48/16
oral
Solubilizer for low log P APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into micellar solution—LFCS Type IV. Use in melt processes (granulation, extrusion), granulation, and compression. Wetting agent.
Gelucire 50/13
oral
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into coarse emulsion—LFCS Type III (SMEDDS). Modulation of drug release. Lipid binder in melt processes.
-
Labrafac Lipophile WL1349
oral & topical
Oily vehicle in LFCS Type I, Type II (SEDDS), and Type III formulations (SMEDDS). Oil phase for topical formulations. Oily vehicle and solubilizer for solutions (parenteral, auricular).
-
Labrafac PG
topical
Oily phase for topical formulations. Oily vehicle and solubilizer for solutions.
Labrafil M1944CS
oral & topical
Solubilizer for poorly-soluble API and bioavailability enhancer Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion – LFCS type II (SEDDS) Combine with Labrasol®ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS) Co-emulsifier in topical formulations often associated with Tefose® 63 in antifungal cream
filing No. available
Labrafil M2125CS
oral
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS).
-
Labrafil M2130CS
topical
Co-emulsifier in topical formulations often associated with Tefose® 63. Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS).
Labrasol
topical
Solubilizer and O/W surfactant for microemulsion. Able to form light foams with pump device (no gas required).
Labrasol ALF
oral
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). High purity guaranteed for stability and capsule compatibility.
Lauroglycol 90
oral & topical
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation.
-
Lauroglycol FCC
topical
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation.
filing No. available
Maisine CC
oral
Solubilizer for lipophilic API and bioavailability enhancer. Oily vehicle for LFCS Type I (oily), Type II (SEDDS) and Type III (SMEDDS), associated with lymphatic absorption.
Monosteol
topical
Consistency agent for oily phase in topical formulations. Stability-improving agent.
Peceol
oral & topical
Solubilizer for lipophilic APIs and bioavailability enhancer. Oily vehicle containing long-chain fatty acids (C18:2) for LFCS Type I (oily), Type II (SEDDS), and Type III (SMEDDS), associated with lymphatic absorption. Oily vehicle for topical formulations.
Plurol Diisostearique
topical
PEG-free W/O emulsifier for topical formulations Ideal for heat-sensitive API Stabilizes and improves sensorial and texture properties
-
Plurol Oleique CC497
oral & topical
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulations.
Precirol ATO 5
oral
Coating agent for taste masking. Lubricant and flow aid for capsule filling with powders. Modified release matrix former for tablets.
-
Sedefos 75
topical
Emulsifier for anhydrous topical formulations. Emulsifier for difficult-to-formulate emulsions (solvents and large oily phase). Stabilizes and improves sensorial and texture properties.
-
Suppocire range
rectal & vaginal
Highly versatile and compatible hard fat suppository base with precedence of use with a wide range of APIs.
Tefose 63
topical
Versatile emulsifier for challenging topical formulations. Widely used with antimicrobials (azole family). Frequently used with the co-emulsifier Labrafil® M 1944 CS to improve stability. Delivers sensorial and texture properties.
Tefose 1500
topical
Polyvalent emulsifier compatible with all types of oils and ideal for topical lotions. Stabilizes and improves sensorial and texture properties.
-
Tefose 2000
topical
A nonionic oil-in-water emulsifier for topical emulsions.
Trancutol HP
oral
Solvent and powerful solubilizer. Cosolvent in surfactant oral formulations—LFCS Type III (SMEDDS) and Type IV (micellar solutions). Vehicle in parenteral, nasal, ophthalmic formulations.
Trancutol P
topical
Solvent and powerful solubilizer. Penetration enhancer for topical formulations.
Trancutol V
topical
Solvent and powerful solubilizer. Penetration enhancer for topical formulations. Vehicle in topical, parenteral and auricular formulations.
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